![allis_grunstein_combo_image3](https://laskerfoundation.org/wp-content/uploads/2021/02/allis_grunstein_combo_image3.jpg)
C. David Allis and Michael Grunstein
David Allis and Michael Grunstein for discoveries elucidating how gene expression is influenced by chemical modification of histones—the proteins that package DNA within chromosomes
![john_glen2](https://laskerfoundation.org/wp-content/uploads/2021/02/john_glen2.jpg)
John B. Glen
John Glen for the discovery and development of propofol, the most widely used agent for induction of anesthesia in patients throughout the world
![joan_steitz2](https://laskerfoundation.org/wp-content/uploads/2021/02/joan_steitz2.jpg)
Joan Argetsinger Steitz
Joan Argetsinger Steitz for four decades of leadership in science
![Roy Fox Lichtenstein Roy Fox Lichtenstein](https://laskerfoundation.org/wp-content/uploads/2018/09/goldstein_promo_chip_1-710.jpg)
What Makes a Piece of Art or Science a Masterpiece?
Critics of art and philosophers of science have long wrestled with the question of what elevates a piece of art or a set of experiments to masterpiece status.