To celebrate our 75th anniversary, we are publishing exclusive profiles and videos about our Laureates every month. In this issue, J. Michael Bishop and Harold Varmus talk about their 20-year partnership that led to the discovery of oncogenes, and Eric Kandel discusses how studying sea slugs revealed the mechanisms underlying learning and memory. We also feature the first chapter of a multipart interview with Nancy Wexler about her lifelong mission to find a cure for Huntington’s disease.