Peter Ratcliffe, Director of the Target Discovery Institute at the University of Oxford, delivered the 2018 Lasker APSA Lecture at the annual meeting of the American Physician Scientists Association on April 20. Ratcliffe spoke about his research in elucidating cellular oxygen sensing pathways. He also discussed the important role that physcian-scientists play applying basic science to advance clinical research. Ratcliffe is a recipient of the 2016 Albert Lasker Basic Medical Research Award for oxygen sensing.