The 2011 Lasker Lecture, “Induction of Pluripotency by Defined Factors,” was delivered by Shinya Yamanaka to a packed auditorium at the Albert Einstein College of Medicine on October 24, 2011. Shinya Yamanaka provided a personal perspective on his revolutionary work to uncover the factors that induce somatic cells into becoming pluripotent stem cells. Following Shinya Yamanaka, Paul Frennette discussed his research in a talk entitled “Neural Control of Stem Cell and Cancer Microenvironments.”