In this issue, we talk with three Lasker Laureates. Phillip Sharp tells us how focusing on fundamental science can lead to clinical breakthroughs. Alfred Sommer discusses the power of perseverance in making meaningful change in public health. Evelyn Witkin details her half-century career studying bacterial genetics. Lastly, in the second chapter of her video interview, Nancy Wexler shares her journey to identify the gene that causes Huntington’s disease.