Structures and functions of low-complexity domainsDirk Görlich, Steven L. McKnightLasker Admin2025-10-01T14:13:43-04:00Year of awards: 2025| Awards: BASIC|
cGAS enzyme that senses self and foreign DNAZhijian “James” ChenLasker Admin2025-09-02T11:18:03-04:00Year of awards: 2024| Awards: BASIC|
AlphaFold—for predicting protein structuresDemis Hassabis, John JumperLasker Admin2025-09-02T11:24:22-04:00Year of awards: 2023| Awards: BASIC|
Integrins—mediators of cell-matrix and cell-cell adhesionRichard O. Hynes, Erkki Ruoslahti, Timothy A. SpringerLasker Admin2025-09-02T11:35:15-04:00Year of awards: 2022| Awards: BASIC|
Light-sensitive microbial proteins and optogeneticsKarl Deisseroth, Peter Hegemann, Dieter OesterheltLasker Admin2025-09-02T11:44:07-04:00Year of awards: 2021| Awards: BASIC|
B and T cells—the organizing principle of the adaptive immune systemMax D. Cooper, Jacques MillerLasker Admin2025-09-02T11:53:46-04:00Year of awards: 2019| Awards: BASIC|
Histone modifications and gene expressionC. David Allis, Michael GrunsteinLasker Admin2025-09-02T11:58:54-04:00Year of awards: 2018| Awards: BASIC|
Nutrient-activated TOR proteins that regulate cell growthMichael N. HallLasker Admin2021-02-27T15:27:24-05:00Year of awards: 2017| Awards: BASIC|
Oxygen sensing – an essential process for survivalWilliam G. Kaelin, Jr., Peter J. Ratcliffe, Gregg L. SemenzaLasker Admin2021-05-27T15:40:33-04:00Year of awards: 2016| Awards: BASIC|
Discoveries concerning the DNA-damage responseStephen J. Elledge, Evelyn M. WitkinLasker Admin2021-02-27T15:33:01-05:00Year of awards: 2015| Awards: BASIC|
Unfolded protein responseKazutoshi Mori, Peter WalterLasker Admin2021-02-27T15:35:15-05:00Year of awards: 2014| Awards: BASIC|
Regulated neurotransmitter releaseRichard H. Scheller, Thomas C. SüdhofLasker Admin2021-02-27T15:37:34-05:00Year of awards: 2013| Awards: BASIC|
Motor proteins that contract muscles and enable cell movementsMichael Sheetz, James Spudich, Ronald ValeLasker Admin2021-02-27T15:40:12-05:00Year of awards: 2012| Awards: BASIC|
Chaperone-assisted protein foldingFranz-Ulrich Hartl, Arthur L. HorwichLasker Admin2021-02-27T15:42:47-05:00Year of awards: 2011| Awards: BASIC|
Leptin, a hormone that regulates appetite and body weightDouglas Coleman, Jeffrey M. FriedmanLasker Admin2021-02-27T15:45:47-05:00Year of awards: 2010| Awards: BASIC|
Nuclear reprogramming: converting specialized cells into early stem cellsJohn Gurdon, Shinya YamanakaLasker Admin2021-02-27T15:47:34-05:00Year of awards: 2009| Awards: BASIC|
